We know regular exposure to certain substances – caffeine, alcohol or THC – can change how our body responds to them over time, so it's inevitably a popular question. Does tolerance apply to CBD – or does it work differently?
Current research suggests that CBD does not appear to cause traditional tolerance in the way some other compounds do. But like all aspects of wellbeing, there's nuance. We're here to help you get the most from your CBD routine, now and in the long term.
What is CBD tolerance?
Tolerance in general is when the same dose of a substance produces a weaker effect over time. Your body becomes accustomed to its presence, and eventually, you may need more to get the same result. This can happen with substances that act on the brain's reward system, such as nicotine or THC. But not all compounds lead to tolerance in the same way.
In fact, a 2018 study found that CBD may work in reverse, helping to restore balance in systems that have become overstimulated by other substances.
Does CBD cause tolerance?
Unlike THC, which binds directly to CB1 receptors in the brain (and is associated with psychoactive effects and tolerance build-up), CBD works differently. It doesn't bind to cannabinoid receptors in the same way. Instead, it modulates how the endocannabinoid system (ECS) functions, helping to maintain internal balance – or homeostasis.
Because of this, many researchers believe CBD is less likely to trigger the same kind of tolerance mechanism that we see with THC. A 2011 review concluded that CBD has a favourable safety profile and does not induce tolerance, even at high doses.
That said, the conversation isn't entirely closed.
What does current CBD research say?
While high-quality, long-term studies in healthy populations are still limited, one study often referenced in this context is a 2020 investigation into patients with treatment-resistant epilepsy.
In the study, patients were treated with a 20:1 CBD:THC ratio cannabis oil and researchers defined tolerance as either a 30% increase in dose to maintain effect or a 30% increase in seizure frequency. After around seven months, tolerance (by that definition) was observed in 25% of participants.
However, this study involved very high doses of medical cannabis and was focused on a specific clinical condition. It does not necessarily reflect how over-the-counter CBD products are used or how they affect otherwise healthy individuals using CBD for everyday wellbeing support.
Most commercially available CBD supplements contain moderate, precisely measured doses designed for gentle, daily support with minimal risk of unwanted effects.
Can tolerance still develop over time?
Technically, it's possible to notice changes in how your body responds to CBD, particularly if you're taking high doses for long periods without variation. But this isn't necessarily "tolerance" in the way we think of it with substances like caffeine or alcohol.
Instead, what some people can experience is a plateau – a point where the benefits feel less noticeable, especially if expectations are high or lifestyle factors change. For example, if you're using CBD to support sleep during a stressful period and that stress subsides, you might feel the effects less. This isn't because the CBD is “doing less,” but because your baseline has shifted.
How to maximise CBD's effectiveness over time
If you're looking to maintain the benefits of CBD, there are a few tried-and-tested strategies that can help.
1. Keep it consistent
Your endocannabinoid system thrives on balance, not extremes. Regular, consistent use of CBD is more effective than sporadic or reactive use. It helps your body maintain a stable response and encourages a cumulative effect over time.
CBD gummies are a great way to build a consistent daily habit. Each contains 25mg of CBD – no guesswork or measuring.
2. Start low and adjust slowly
A common mistake is increasing your dose too quickly in the belief that more equals better. But when it comes to CBD, lower, steady doses often deliver more sustainable results.
If you're just starting to take CBD or feel you're not getting the same benefits as before, consider reducing your dose for a few days and then slowly reintroducing it. This can help you “reset” and give your endocannabinoid system (ECS) space to recalibrate. CBD works best when taken consistently and in the right amount for your body. Understanding how to dose CBD can help you find that balance more effectively.
3. Support your ECS naturally
CBD is one tool for supporting your ECS, but it's not the only one. Things like sleep, movement, hydration, a diet rich in omega-3s and mindfulness practices all help your body stay balanced.
Think of CBD as part of a wider wellbeing toolkit, not a standalone fix.
Can you take a tolerance break from CBD?
If you've been using CBD for a while and feel the benefits aren't what they used to be, taking a short break might help. A “tolerance break” isn't always necessary with CBD, but pausing for a few days can help you reconnect with how your body responds – especially if your routine or stress levels have changed. During this time, focus on other wellness habits, stay hydrated and resume your CBD intake with a low, intentional dose when you return.
There's no strong evidence that CBD causes traditional tolerance in healthy users, especially when taken at moderate doses, as part of a balanced routine. But our bodies change. Lifestyle shifts, stress, diet and sleep can all impact how CBD works for us. That's why it's helpful to approach CBD with curiosity and flexibility, adjusting your dose or routine when needed.
Calm isn't something you force – it's something you support. Our CBD oils, drinks and gummies are designed to work with your body, helping you feel the benefits of CBD day after day – no need to chase bigger doses, just steady, natural support that fits into real life.
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This article is for informational purposes only and does not constitute medical advice. Please consult your healthcare provider before starting any new supplement, especially if you are pregnant, breastfeeding or taking other medications.